Probé pythonnet con pypy en Win10. Se construye bien, pero luego falla al import clr . El bloqueo ocurre después de esta llamada en la captura de pantalla.

¿Algún consejo/herramienta para depurar esto?

 pypy Python 2.7.12 (aff251e54385, Nov 09 2016, 17:54:55) [PyPy 5.6.0 with MSC v.1500 32 bit] on win32 Type "help", "copyright", "credits" or "license" for more information. >>>> import clr Attempting to load 'Python.Runtime' using standard binding rules. 'Python.Runtime' not found using standard binding rules. Attempting to load Python.Runtime from: 'C:\Python\pypy2-v5.6.0-win32\site-packages\Python.Runtime.dll'. Success loading 'Python.Runtime' from: 'C:\Python\pypy2-v5.6.0-win32\site-packages\Python.Runtime.dll'. RPython traceback: File "pypy_module_cpyext_2.c", line 26114, in type_realize File "pypy_module_cpyext_2.c", line 31744, in _type_realize Fatal RPython error: AssertionError This application has requested the Runtime to terminate it in an unusual way. Please contact the application's support team for more information.

Aquí está el hilo detallado sobre el problema.