You can't run the Typescript code by passing it to Node.js directly, Node.js doesn't provide native support for executing Typescript. The code has to be either compiled on-the-fly or precompiled. here are some recipes:

• To run a selected TypeScript file using ts-node:

  • Install ts-node using npm i ts-node.
  • Create a new Node.js run/debug configuration.
  • Add --require ts-node/register to the Node parameters field.
  • In the JavaScript file field add $FilePathRelativeToProjectRoot$.
  • Save configuration.
  • Use it to run (or debug) a file that is currently opened in the editor or selected in the Project view. You can do that using the icons on the navigation bar or Run... action.

If you need to pass any additional parameters to ts-node (e.g. --project tsconfig.json), you can add them to the Application parameters field in the run/debug configuration.

• To compile app with TypeScript and run a selected TypeScript file

  • Create a Node.js run/debug configuration.
  • In the Before Launch section, click Add and select Compile TypeScript.
    • Select tsconfig.json.
    • In the JavaScript file field you need to select the path to the compiled .js file.
    • If a compiled JavaScript lives next to its source, add $FileRelativeDir$/$FileNameWithoutExtension$.js
    • If files are saved in an output folder (preserving the folder structure), add the folder name before the pattern, e.g. build/$FileRelativeDir$/$FileNameWithoutExtension$.js
    • Save configuration.
    • Use it to run (or debug) a file that is currently opened in the editor or selected in the Project view.

I think you should adjust your tsconfig.json file and add a new start script, I think maybe the global script you trying to run can't find the ts-node module

{
  "compilerOptions": {
    "target": "ES2018",
    "module": "commonjs",
    "lib": [
      "es2018"
    ],
    "declaration": true,
    "strict": true,
    "noImplicitAny": true,
    "strictNullChecks": true,
    "noImplicitThis": true,
    "alwaysStrict": true,
    "noUnusedLocals": false,
    "noUnusedParameters": false,
    "noImplicitReturns": true,
    "noFallthroughCasesInSwitch": false,
    "inlineSourceMap": true,
    "inlineSources": true,
    "experimentalDecorators": true,
    "strictPropertyInitialization": false,
    "typeRoots": [
      "./node_modules/@types"
    ]
  },
  "exclude": [
    "node_modules",
  ]
}

###Add new start in your package.json

  "scripts": {
    "start": "npx ts-node src/index.ts"
  },