Pruebe esta solución.

Paso - 1. Obtenga la diferencia horaria entre ambas fechas

 const date1 = new Date("04/09/2022 06:16:49"); const date2 = new Date("04/14/2022 12:49:29"); const diff = date2.getTime() - date1.getTime(); console.log(diff); // Will display 455560000 ie miliseconds

Paso - 2 Convertir milisegundos a segundos

 let seconds = diff / 1000; // Will return seconds

Paso - 3 Convertir segundos a Horas

 const hours = parseInt( seconds / 3600 ); // 3,600 seconds in 1 hour seconds = seconds % 3600;

Paso - 4 Convertir segundos a minutos

 const minutes = parseInt( seconds / 60 ); seconds = seconds % 60; console.log(hours+":"+minutes+":"+seconds)