You appear to have an array of strings where the strings are byte values written as hexadecimal strings. So you need to:

• Convert each hex string to a byte; that's easily done with parseInt(str, 16) (the 16 being hexadecimal). parseInt will allow the 0x prefix. Or you could use +str or Number(str) since the prefix is there to tell them what number base to use. (More about various ways to convert strings to numbers in my answer here.)
• Create a buffer and fill it in with the bytes.

If the array isn't massive and you can happily create a temporary array, use map and Buffer.from:

const buffer = Buffer.from(theArray.map(str => +str)));

If you want to avoid any unnecessary intermediate arrays, I'm surprised not to see any variant of Buffer.from that allows mapping, so we have to do those things separately:

const buffer = Buffer.alloc(theArray.length);
for (let index = 0; index < theArray.length; ++index) {
    buffer[index] = +theArray[index];
}